In this season, Randall, Kate, and Kevin find themselves on new paths as they celebrate their 38th birthdays.

In the season premiere, the doctors at Grey Sloan Memorial vie for a new position. Meredith is seemingly distracted and struggles to stay focused, and Maggie finds herself the keeper of a big secret while Amelia and Owen try to figure out their relationship. Meanwhile, Jo and Alex's honeymoon doesn't go exactly as planned.